Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336434 | 0.83 | APP (0.47) | CA12CA1CA2CA4CA7 | |
| SCHEMBL5321804 | 0.82 | HDAC4 (0.48) | SYKCA12CA1CA2CA7 | |
| SCHEMBL11513962 | 0.81 | ALDH1A1 (0.40) | ALDH1A1PTGS1KDM4EMAPTHSD17B10 | |
| SCHEMBL5329513 | 0.81 | ALDH1A1 (0.44) | ERN1SLC9A1SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL6618767 | 0.79 | FPR2 (0.34) | ERN1CA12CA1CA2CA4 | |
| SCHEMBL6054816 | 0.78 | HTR7 (0.43) | CA2SMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL5326722 | 0.78 | NISCH (0.38) | SLC9A1LRRK2MEN1HPGDKMT2A | |
| SCHEMBL5325455 | 0.78 | PTPN1 (0.40) | SLC9A1S1PR1CA9CA14MEN1 | |
| SCHEMBL13729257 | 0.77 | CREBBP (0.41) | ERN1SLC9A1JAK2JAK3S1PR1 | |
| SCHEMBL5327699 | 0.77 | AR (0.47) | LRRK2STK10SLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |