Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 2/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11616908 | 0.79 | KDM1A (0.56) | ARKDM1ALRRK2PTGDR2EGLN2 | |
| SCHEMBL5321804 | 0.78 | HDAC4 (0.48) | AR | |
| SCHEMBL11513962 | 0.77 | ALDH1A1 (0.40) | IMPDH2IMPDH1 | |
| SCHEMBL5326536 | 0.77 | ERN1 (0.40) | LRRK2STK10SLK | |
| SCHEMBL5329513 | 0.77 | ALDH1A1 (0.44) | — | |
| SCHEMBL29788111 | 0.76 | PTGDR2 (0.60) | ARKDM1APTGDR2MAOAMAOB | |
| SCHEMBL16429066 | 0.76 | PTGDR2 (0.60) | ARKDM1APTGDR2MAOAMAOB | |
| SCHEMBL336434 | 0.76 | APP (0.47) | — | |
| SCHEMBL5327702 | 0.75 | KDM1A (0.58) | ARKDM1APTGDR2MAOAMAOB | |
| SCHEMBL6054816 | 0.75 | HTR7 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |