Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 11/20 | 0.49 |
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.47 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.45 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5328852 | 1.00 | HTR1A (0.49) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL4522586 | 0.94 | HTR1A (0.51) | HTR1AHTR7DRD2DRD3HTR2A | |
| Maleic Acid SCHEMBL5326369 | 0.93 | HTR1A (0.50) | HTR1AHTR7DRD2DRD3HTR2A | |
| Fumaric Acid SCHEMBL5326379 | 0.93 | HTR1A (0.50) | HTR1AHTR7DRD2DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL4517673 | 0.93 | HTR1A (0.51) | HTR1AHTR7DRD2DRD3HTR2A | |
| Succinic Acid SCHEMBL5309268 | 0.92 | HTR1A (0.48) | HTR1AHTR7DRD2DRD3HTR2A | |
| Cadaverine Tartrate SCHEMBL5327025 | 0.91 | HTR1A (0.46) | HTR1AHTR7DRD2DRD3HTR2A | |
| Phosphoric Acid SCHEMBL5327365 | 0.91 | HTR1A (0.49) | HTR1AHTR7DRD2DRD3HTR2A | |
| Maleic Acid SCHEMBL5303503 | 0.90 | HTR1A (0.43) | HTR1AHTR7DRD2DRD3HTR2A | |
| Fumaric Acid SCHEMBL5303510 | 0.90 | HTR1A (0.43) | HTR1AHTR7DRD2DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | claimed |
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | disclosed |