SCHEMBL5328862

SCHEMBL5328862

CNS(=O)(=O)c1cc(C(=O)CCC[CH]C(C)(C)C)cc2c1CCC2

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 11/20 0.34
CA2 P00918 1/20 0.32
CNR1 P21554 1/20 0.32
CNR2 P34972 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5311322 0.83 NLRP3 (0.34) NLRP3CA2TDP1
SCHEMBL5313768 0.81 PTGS2 (0.47) TDP1PTGS1PTGS2
SCHEMBL5311622 0.72 PTGS1 (0.45) PTGS1PTGS2
SCHEMBL5577157 0.71 SLC2A1 (0.37) TDP1
Hydrochloric Acid SCHEMBL5310762 0.70 SLC2A1 (0.36) TDP1
SCHEMBL5576958 0.69 DRD2 (0.36) TDP1
SCHEMBL5328513 0.69 NPC1 (0.35) NLRP3CA2PTGS1PTGS2
SCHEMBL5307851 0.69 NPC1 (0.34) NLRP3PTGS1PTGS2
SCHEMBL5310504 0.68 NPC1 (0.37) NLRP3CA2PTGS1PTGS2
SCHEMBL27611281 0.65 PTGS2 (0.49) CA2TDP1PTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007052831-A1 PREVENTIVES/REMEDIES FOR URINARY DISTURBANCE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-05-10 WO disclosed