Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564064 | 0.76 | APP (0.44) | MAPTAPPALDH1A1ALOX15NPC1 | |
| SCHEMBL6564084 | 0.74 | APP (0.42) | MAPTAPPMAPK1ALDH1A1NPC1 | |
| SCHEMBL6562532 | 0.73 | MAPT (0.41) | MAPTAPPALDH1A1ALOX15NPC1 | |
| SCHEMBL6563098 | 0.71 | APP (0.48) | MAPTAPPALDH1A1NPC1MTOR | |
| SCHEMBL28592261 | 0.69 | MAPT (0.49) | MAPTAPPALDH1A1ALOX15 | |
| SCHEMBL523695 | 0.68 | MAPT (0.51) | MAPTAPPMAPK1ALDH1A1ALOX15 | |
| SCHEMBL2183993 | 0.68 | APP (0.55) | MAPTAPPALDH1A1ALOX15NPC1 | |
| SCHEMBL562815 | 0.68 | APP (0.55) | MAPTAPPALDH1A1NPC1MTOR | |
| SCHEMBL6561445 | 0.68 | MAPT (0.44) | MAPTAPPALDH1A1NPC1MTOR | |
| SCHEMBL6562626 | 0.68 | MAPT (0.40) | MAPTAPPNPC1MTORRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007134421-A1 | 2-VINYL INDOLES, PYRIDO AND AZEPINO INDOLE DERIVATIVES, 2-ALKYNYL INDOLES, 2-ALKYNYL BENZO[b]FURANS, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | LAUTENS MARK (CA) | 2007-11-29 | — | — | WO | disclosed |