Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | MARS1 | P56192 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5180982 | 0.84 | JAK2 (0.39) | JAK2SCN9ATP53POLBMAPT | |
| SCHEMBL5570998 | 0.83 | DHODH (0.41) | JAK2POLBMAPTF2RL3SCN5A | |
| SCHEMBL5252750 | 0.81 | KCNQ3 (0.38) | JAK2SCN9ATP53POLBMAPT | |
| SCHEMBL312326 | 0.74 | TGFBR1 (0.52) | TP53POLBMAPTSCN5ACYP2C8 | |
| SCHEMBL20190163 | 0.70 | SCN5A (0.50) | JAK2SCN9APOLBMAPTF2RL3 | |
| SCHEMBL312268 | 0.68 | LMNA (0.61) | TP53POLBMAPT | |
| SCHEMBL1348829 | 0.67 | ADORA3 (0.39) | TP53POLBMAPTP2RY14ADORA3 | |
| SCHEMBL5180976 | 0.65 | SCN5A (0.53) | MAPTSCN5A | |
| SCHEMBL4867147 | 0.65 | KCNQ3 (0.52) | JAK2DHODHPTGER1 | |
| SCHEMBL1348731 | 0.64 | SCN5A (0.52) | JAK2POLBMAPTF2RL3SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851225-A1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006084634-A1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-17 | — | — | WO | disclosed |