Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY6 | O43306 | 1/20 | 0.52 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.52 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.52 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.52 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.52 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.52 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.52 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.52 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5325253 | 0.98 | ADCY6 (0.53) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL5325264 | 0.82 | ADCY6 (0.49) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL217308 | 0.73 | MAPT (0.59) | KEAP1MAPTMEN1KMT2AALOX5 | |
| Bromide SCHEMBL11167892 | 0.73 | ADCY6 (0.95) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL5793449 | 0.71 | ADCY6 (1.00) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL31237011 | 0.70 | BCL2 (0.55) | MEN1KMT2AALOX5 | |
| Bromide SCHEMBL10703420 | 0.70 | DRD2 (0.76) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL14282073 | 0.68 | HTR2C (0.56) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL4936396 | 0.68 | HTR2C (0.56) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL278523 | 0.68 | MAPT (0.78) | KEAP1MAPTMEN1KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007149728-A2 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | ALCON RESEARCH, LTD. (US) | 2007-12-27 | — | — | WO | claimed |
| US-20070293475-A1 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | ALCON MANUFACTURING LTD. (US) | 2007-12-20 | — | — | US | claimed |
| WO-2007149728-A2 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | ALCON RESEARCH, LTD. (US) | 2007-12-27 | — | — | WO | disclosed |
| US-20070293475-A1 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | ALCON MANUFACTURING LTD. (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293475-A1 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | HTR2B, HTR2A, HTR3B | ADCY6 1204/4885ADCY3 701/4885ADCY9 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.