Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534153 | 0.85 | MAPT (0.58) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL533022 | 0.84 | MEN1 (0.52) | MEN1KMT2AGAASMN1; SMN2NPC1 | |
| SCHEMBL534076 | 0.82 | POLB (0.53) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL533064 | 0.81 | MAPT (0.56) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL532973 | 0.80 | MAPT (0.44) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL532826 | 0.79 | ALDH1A1 (0.47) | GAAALDH1A1POLBSMN1; SMN2NPSR1 | |
| SCHEMBL532801 | 0.79 | GAA (0.48) | MEN1KMT2AGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL532964 | 0.79 | L3MBTL1 (0.47) | MEN1KMT2AGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL532950 | 0.79 | KMT2A (0.56) | MEN1KMT2AGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL533514 | 0.78 | RAB9A (0.51) | MEN1KMT2AGAAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |