Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.42 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530606 | 0.96 | DRD2 (0.47) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL4515496 | 0.96 | DRD2 (0.47) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| SCHEMBL5330072 | 0.92 | HTR1A (0.40) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| Succinic Acid SCHEMBL5331536 | 0.92 | DRD2 (0.43) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| Maleic Acid SCHEMBL5328849 | 0.91 | DRD2 (0.43) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| Fumaric Acid SCHEMBL5328856 | 0.91 | DRD2 (0.43) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| Cadaverine Tartrate SCHEMBL5330833 | 0.91 | DRD2 (0.43) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| Phosphoric Acid SCHEMBL5330246 | 0.88 | HTR1A (0.46) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| Phosphoric Acid SCHEMBL5302008 | 0.84 | DRD2 (0.48) | DRD2HTR1AHTR2AADRA1AADRA1D | |
| Phosphoric Acid SCHEMBL5329987 | 0.84 | HTR1A (0.45) | DRD2HTR1AHTR2AADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | disclosed |