Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPRB | P23467 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5066827 | 0.85 | HCAR2 (0.83) | HCAR2RAB9ANPC1FFAR1PTPN2 | |
| SCHEMBL5294571 | 0.84 | HCAR2 (0.71) | HCAR2RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL5330760 | 0.81 | HCAR2 (0.72) | HCAR2RAB9ANPC1PTPN2PTPRB | |
| SCHEMBL5300923 | 0.76 | HCAR2 (0.65) | HCAR2RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL13781575 | 0.75 | HCAR2 (0.73) | HCAR2RAB9ANPC1CYP2C8CYP2C9 | |
| SCHEMBL5308463 | 0.75 | HCAR2 (0.64) | HCAR2RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL13781546 | 0.74 | HCAR2 (0.62) | HCAR2RAB9ANPC1PTPN2PTPRB | |
| SCHEMBL5061069 | 0.73 | RAB9A (0.86) | HCAR2RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL10741084 | 0.72 | PTPN2 (0.62) | HCAR2RAB9ANPC1PTPN2PTPRB | |
| SCHEMBL5301445 | 0.72 | RAB9A (0.70) | HCAR2RAB9ANPC1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |