Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 11/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.54 |
| ▸ | USP2 | O75604 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380842 | 0.87 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL5312963 | 0.84 | STAT1 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL5313913 | 0.76 | CLK4 (0.52) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL24466947 | 0.76 | NPR1 (0.66) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL3932470 | 0.75 | EGFR (0.59) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL4071128 | 0.75 | EGFR (0.62) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL4069915 | 0.73 | EGFR (0.72) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL4072924 | 0.73 | CLK4 (0.57) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL4066517 | 0.72 | CLK4 (0.52) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL5474360 | 0.72 | CLK4 (0.69) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056208-A2 | N-ARYLALKYL-THIENOPYRIMIDIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| US-20070099941-A1 | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-05-03 | — | — | US | claimed |
| US-20070099941-A1 | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099941-A1 | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP10, CASP3, CASP4 | CYP1A2 795/4885CYP3A4 601/4885CYP2D6 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.