Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323602 | 0.76 | HSD11B1 (0.58) | PARP1GPR55HSD11B1CYP3A4KMT2A | |
| SCHEMBL4084359 | 0.76 | ALDH1A1 (0.46) | PARP1GPR55NPC1HPGDRAB9A | |
| SCHEMBL12319896 | 0.68 | HSD11B1 (0.59) | HPGDTSHRHSD11B1ALDH1A1HDAC8 | |
| SCHEMBL11471858 | 0.67 | HPGD (0.50) | PARP1NPC1HPGDRAB9ATP53 | |
| SCHEMBL12181191 | 0.67 | RAB9A (0.58) | PARP1NPC1HPGDRAB9ATP53 | |
| SCHEMBL12216734 | 0.64 | KDM4E (0.62) | NPC1HPGDRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL3749708 | 0.63 | P2RX7 (0.51) | ALDH1A1KMT2AHSD17B10MEN1 | |
| SCHEMBL24667217 | 0.63 | HPGD (0.46) | PARP1NPC1HPGDRAB9ATP53 | |
| SCHEMBL28311788 | 0.62 | HPGD (0.57) | PARP1NPC1HPGDRAB9ATP53 | |
| SCHEMBL29599185 | 0.62 | ALDH1A1 (0.53) | PARP1NPC1HPGDRAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861384-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006100502-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | STERIX LIMITED (GB) | 2006-09-28 | — | — | WO | disclosed |