Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GRN | P28799 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP9 | P55211 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522003 | 0.85 | KDM4E (0.49) | PKMKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL4759203 | 0.83 | PKM (0.61) | PKMKDM4EALDH1A1GRNSORT1 | |
| SCHEMBL24425293 | 0.79 | ALDH1A1 (0.51) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL20797378 | 0.78 | PKM (0.71) | PKMKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL17473467 | 0.77 | KDM4E (0.47) | PKMKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL27114081 | 0.77 | KDM4E (0.44) | PKMKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL24408948 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL21607915 | 0.76 | LMNA (0.52) | KDM4EALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL14292543 | 0.76 | KDM4E (0.46) | PKMKDM4EALDH1A1GRNSORT1 | |
| SCHEMBL7703521 | 0.76 | LMNA (0.52) | KDM4EALDH1A1SMN1; SMN2MAPTGRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205403-B2 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2007-04-17 | — | — | US | disclosed |