Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2124453 | 0.88 | TGFBR1 (0.36) | TGFBR1 | |
| SCHEMBL9451823 | 0.78 | TGFBR1 (0.42) | TGFBR1ALDH1A1 | |
| Fluoride Ion SCHEMBL8934072 | 0.77 | TGFBR1 (0.41) | TGFBR1 | |
| Hydrochloric Acid SCHEMBL4764541 | 0.76 | TGFBR1 (0.43) | TGFBR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL61003 | 0.76 | TGFBR1 (0.43) | TGFBR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4920381 | 0.75 | TGFBR1 (0.42) | TGFBR1ALDH1A1 | |
| SCHEMBL33606 | 0.74 | TGFBR1 (0.44) | TGFBR1ALDH1A1 | |
| SCHEMBL12027706 | 0.74 | TGFBR1 (0.34) | TGFBR1 | |
| Hydrochloric Acid SCHEMBL10425311 | 0.74 | TGFBR1 (0.39) | TGFBR1 | |
| Hydrochloric Acid SCHEMBL10337216 | 0.74 | TGFBR1 (0.42) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539676-B1 | MONOMER COMPOUND COMPRISING SEVERAL CATIONIC GROUPS, PROCESS FOR MAKING THE SAME, AND POLYMERS COMPRISING UNITS DERIVING THEREFROM | SOLVAY USA INC (US) | 2017-07-26 | — | — | EP | disclosed |
| EP-2644592-A1 | Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom | RHODIA INC. (US) | 2013-10-02 | — | — | EP | disclosed |
| US-7247693-B2 | Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom | RHODIA INC. (US) | 2007-07-24 | — | — | US | disclosed |
| EP-1539676-A4 | MONOMER COMPOUND COMPRISING SEVERAL CATIONIC GROUPS, PROCESS FOR MAKING THE SAME, AND POLYMERS COMPRISING UNITS DERIVING THEREFROM | RHODIA (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20060111533-A1 | Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom | RHODIA OPERATIONS (FR) | 2006-05-25 | — | — | US | disclosed |
| US-7030275-B2 | Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom | RHODIA INC. (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1539676-A1 | MONOMER COMPOUND COMPRISING SEVERAL CATIONIC GROUPS, PROCESS FOR MAKING THE SAME, AND POLYMERS COMPRISING UNITS DERIVING THEREFROM | Rhodia Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20040010106-A1 | Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom | RHODIA OPERATIONS (FR) | 2004-01-15 | — | — | US | disclosed |
| WO-2003101935-A1 | MONOMER COMPOUND COMPRISING SEVERAL CATIONIC GROUPS, PROCESS FOR MAKING THE SAME, AND POLYMERS COMPRISING UNITS DERIVING THEREFROM | RHODIA INC. (US) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040010106-A1 | Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom | PCNA, PBRM1, B2M | MGAM 1696/4885GAA 4211/4885SI 3205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.