Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 6/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5331359 | 0.84 | NPC1 (0.38) | NPC1RAB9AKCNH2POLBSMN1; SMN2 | |
| SCHEMBL542216 | 0.79 | KCNH2 (0.42) | IDO1NPC1RAB9AKCNH2GRM5 | |
| SCHEMBL5309293 | 0.78 | NOTUM (0.45) | IDO1NPC1RAB9AKCNH2AR | |
| SCHEMBL5327885 | 0.74 | RAB9A (0.45) | NPC1RAB9APOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL15084169 | 0.74 | NTRK1 (0.40) | NPC1RAB9AARTRPA1P2RX7 | |
| SCHEMBL5802338 | 0.71 | L3MBTL1 (0.38) | NPC1RAB9APOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL5802677 | 0.71 | AR (0.33) | KCNH2ARTRPA1 | |
| SCHEMBL3721862 | 0.69 | CACNA1G (0.42) | NPC1RAB9AKCNH2SMN1; SMN2CACNA1G | |
| SCHEMBL1220435 | 0.69 | MAPT (0.41) | NPC1RAB9APOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL5332143 | 0.69 | GALR3 (0.34) | IDO1GRM5ARSMN1; SMN2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007034445-A2 | NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |
| WO-2006064484-A1 | AZABICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-22 | — | — | WO | disclosed |