Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | MYC | P01106 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405521 | 0.88 | HSD17B10 (0.61) | HSD17B10ALDH1A1NOTUMTDP1MAPT | |
| SCHEMBL12094387 | 0.80 | HAO1 (0.55) | HSD17B10ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL13290538 | 0.77 | KDM4E (0.46) | HSD17B10ALDH1A1TDP1MAPTPOLB | |
| SCHEMBL13666576 | 0.76 | HSD17B10 (0.79) | HSD17B10ALDH1A1TDP1KDM4EHPGD | |
| SCHEMBL1885602 | 0.76 | ALDH1A1 (0.55) | HSD17B10ALDH1A1NOTUMMAPTKDM4E | |
| SCHEMBL30446730 | 0.76 | ALDH1A1 (0.55) | HSD17B10ALDH1A1NOTUMMAPTKDM4E | |
| SCHEMBL11977114 | 0.75 | HDAC1 (0.59) | ALDH1A1NOTUMTDP1MAPTPOLB | |
| SCHEMBL12089746 | 0.75 | NOTUM (0.55) | HSD17B10ALDH1A1NOTUMTDP1MAPT | |
| SCHEMBL16729143 | 0.74 | PLA2G10 (0.48) | HSD17B10ALDH1A1TDP1MAPTPOLB | |
| SCHEMBL29342928 | 0.73 | KMT2A (0.48) | HSD17B10ALDH1A1TDP1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807403-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006046030-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-05-04 | — | — | WO | disclosed |