Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MYC | P01106 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405521 | 0.87 | HSD17B10 (0.61) | NOTUMALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL12092920 | 0.82 | NOTUM (0.42) | NOTUMALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL12089747 | 0.82 | KDM4E (0.43) | NOTUMALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL12078505 | 0.82 | ACLY (0.50) | NOTUMALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17171605 | 0.81 | RAPGEF4 (0.46) | NOTUMALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1664109 | 0.80 | ALDH1A1 (0.53) | NOTUMALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9267750 | 0.79 | POLB (0.46) | NOTUMMEN1KMT2AMAPTPOLB | |
| SCHEMBL121580 | 0.78 | HSD17B10 (0.78) | MAPTPOLBHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL13666581 | 0.75 | HSD17B10 (0.61) | NOTUMPOLBHSD17B10SMN1; SMN2L3MBTL1 | |
| SCHEMBL25431435 | 0.75 | BCL2L1 (0.44) | NOTUMALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012637-B2 | Substituted pyrazinyl acrylic acid compounds for the inhibition of pask | BIOENERGENIX, LLC (US) | 2015-04-21 | — | — | US | disclosed |
| US-20140235579-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX, LLC | 2014-08-21 | — | — | US | disclosed |
| US-20120225846-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX (US) | 2012-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225846-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | PASK, PDXK, PANK2 | NOTUM 2400/4885ALDH1A1 3714/4885MEN1 3040/4885 |
| US-20140235579-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | PASK, PDXK, PANK2 | NOTUM 2400/4885ALDH1A1 3714/4885MEN1 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.