Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353990 | 0.81 | LMNA (0.39) | LMNAKMT2AL3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL356632 | 0.81 | TDP1 (0.42) | LMNAKMT2AL3MBTL1MAPTPOLB | |
| SCHEMBL5332672 | 0.78 | CA2 (0.40) | CA2CYP2D6ALOX5 | |
| SCHEMBL354038 | 0.75 | KMT2A (0.41) | LMNAKMT2ACYP2C19MAPTPOLB | |
| SCHEMBL353848 | 0.74 | SLC2A1 (0.38) | CA2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL354403 | 0.74 | CA2 (0.36) | LMNACA2MAPTPOLBTP53 | |
| SCHEMBL354355 | 0.73 | MAOB (0.59) | LMNAKMT2AL3MBTL1CYP2C19MAPT | |
| SCHEMBL5503364 | 0.72 | CA2 (0.40) | LMNAKMT2ACA2L3MBTL1POLB | |
| SCHEMBL5319188 | 0.72 | RAB9A (0.49) | LMNAKMT2APOLBALDH1A1ALOX5 | |
| SCHEMBL6009871 | 0.72 | CA1 (0.44) | CA2CYP2D6CYP2C9CYP2C19TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836161-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006085149-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-08-17 | — | — | WO | disclosed |