Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002580 | 0.80 | NUDT1 (0.58) | NUDT1TP53CYP2C9NOS1NOS2 | |
| SCHEMBL2314765 | 0.77 | DDAH1 (0.55) | NUDT1TP53CYP2C9NOS1NOS2 | |
| SCHEMBL4773954 | 0.77 | NUDT1 (0.59) | NUDT1TP53CYP2C9NOS1NOS2 | |
| SCHEMBL4347800 | 0.77 | NUDT1 (0.55) | NUDT1TP53CYP2C9NOS1NOS2 | |
| SCHEMBL6216010 | 0.77 | NUDT1 (0.55) | NUDT1TP53CYP2C9NOS1NOS2 | |
| SCHEMBL31587712 | 0.77 | NUDT1 (0.55) | NUDT1TP53CYP2C9NOS1NOS2 | |
| SCHEMBL3967813 | 0.77 | NUDT1 (0.55) | NUDT1TP53CYP2C9NOS1NOS2 | |
| Quinoline SCHEMBL28872941 | 0.77 | NPC1 (0.50) | TP53HPGDDRD4SMN1; SMN2NPC1 | |
| SCHEMBL6614094 | 0.77 | CYP2C9 (0.44) | NUDT1TP53CYP2C9NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL5864683 | 0.76 | NUDT1 (0.53) | NUDT1TP53CYP2C9NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101336262-A | Chromane-substituted 2-alkyl imidazopyridine derivatives and their use as acid pump antagonists | GEN ELECTRIC (US) | 2008-12-31 | — | — | CN | disclosed |
| WO-2007026218-A2 | CHROMANE SUBSTITUTED 2-ALKYL IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS ACID PUMP ANTAGONISTS | PFIZER JAPAN INC. (JP) | 2007-03-08 | — | — | WO | disclosed |
| EP-0517812-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1995-10-18 | — | — | EP | disclosed |
| US-5449682-A | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5412097-A | Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists | MERCK & CO., INC. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5332744-A | Hypotensive, congestive heart failure, intraocular pressure | MERCK & CO., INC. (US) | 1994-07-26 | — | — | US | disclosed |
| US-5240938-A | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |
| US-5187159-A | Hypotensive agents, psychological disorders | MERCK & CO., INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5177074-A | Heterocyclic nitrogen compounds used to treat hypertension, cognitive dysfunction, anxiety or depression | MERCK & CO., INC. (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0517812-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO. INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0513979-A1 | Angiotensin II antagonists incorporating a substituted thiophene or furan | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0510813-A1 | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | disclosed |
| US-5157026-A | Oxo-purines as angiotensin II antagonists | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0503838-A2 | Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-09-16 | — | — | EP | disclosed |
| US-5128327-A | Hypotensive agents; congestive heart failure; antidepressants; anxiolytic agents; cognition activators | MERCK & CO., INC. (US) | 1992-07-07 | — | — | US | disclosed |
| US-5102880-A | Biphenyl imidazotriazine derivatives; Hypotensive and cardiotonic agents | MERCK & CO., INC. (US) | 1992-04-07 | — | — | US | disclosed |
| WO-1991011999-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| EP-0400974-A2 | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |