Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 2/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | PDE5A | O76074 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TPH1 | P17752 | 1/20 | 0.44 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994149 | 0.90 | GAA (0.58) | NUDT1DRD4TP53SMN1; SMN2NPC1 | |
| SCHEMBL8806229 | 0.88 | GAA (0.60) | NUDT1METAP1METAP2DRD4TP53 | |
| SCHEMBL2314765 | 0.85 | DDAH1 (0.55) | NUDT1METAP1METAP2CYP2C9NOS1 | |
| SCHEMBL31587712 | 0.85 | NUDT1 (0.55) | NUDT1METAP1METAP2CYP2C9NOS1 | |
| SCHEMBL4773954 | 0.85 | NUDT1 (0.59) | NUDT1METAP1METAP2CYP2C9NOS1 | |
| SCHEMBL4347800 | 0.85 | NUDT1 (0.55) | NUDT1METAP1METAP2CYP2C9NOS1 | |
| SCHEMBL3967813 | 0.85 | NUDT1 (0.55) | NUDT1METAP1METAP2CYP2C9NOS1 | |
| SCHEMBL6216010 | 0.85 | NUDT1 (0.55) | NUDT1METAP1METAP2CYP2C9NOS1 | |
| SCHEMBL6948805 | 0.84 | PKM (0.57) | NUDT1METAP1METAP2CYP2C9NOS1 | |
| Hydrochloric Acid SCHEMBL5864683 | 0.83 | NUDT1 (0.53) | NUDT1METAP1METAP2CYP2C9NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541486-B1 | Used for treating ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation. | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2003-04-01 | — | — | US | claimed |
| EP-1189889-B1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INT LTD (IE) | 2003-12-17 | — | — | EP | disclosed |
| US-6541486-B1 | Used for treating ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation. | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2003-04-01 | — | — | US | disclosed |