Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | PDE5A | O76074 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002580 | 0.85 | NUDT1 (0.58) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| SCHEMBL4719992 | 0.83 | NUDT1 (0.53) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| SCHEMBL31587712 | 0.81 | NUDT1 (0.55) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| SCHEMBL3967813 | 0.81 | NUDT1 (0.55) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| SCHEMBL4347800 | 0.81 | NUDT1 (0.55) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| SCHEMBL6216010 | 0.81 | NUDT1 (0.55) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| SCHEMBL2314765 | 0.81 | DDAH1 (0.55) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| Hydrochloric Acid SCHEMBL5864683 | 0.80 | NUDT1 (0.53) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| SCHEMBL3960231 | 0.79 | CYP2C9 (0.57) | NUDT1CYP2C9NOS1NOS2METAP1 | |
| SCHEMBL9570423 | 0.79 | CYP2C9 (0.53) | NUDT1CYP2C9NOS1NOS2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106327-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-07 | — | — | US | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| EP-2300485-B1 | PYRROLO-[2, 3-C]-PYRIDINE DERIVATIVES AS P38 KINASE INHIBITING AGENTS | MERCK SHARP & DOHME (US) | 2012-01-18 | — | — | EP | disclosed |
| US-8017605-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. (US) | 2011-09-13 | — | — | US | disclosed |
| US-8017605-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. (US) | 2011-09-13 | — | — | US | disclosed |
| US-20110105430-A1 | PYRROLO [2,3-C] PYRIDINE DERIVATIVES AS P38 KINEASE INHIBITING AGENTS | SAHOO SOUMYA P | 2011-05-05 | — | — | US | disclosed |
| US-20090325953-A1 | P38 KINASE INHIBITING AGENTS | MERCK SHARP & DOHME LLC | 2009-12-31 | — | — | US | disclosed |
| US-20090325953-A1 | P38 KINASE INHIBITING AGENTS | MERCK SHARP & DOHME LLC | 2009-12-31 | — | — | US | disclosed |
| WO-2009152072-A1 | PYRROLO [2, 3-C] PYRIDINE DERIVATIVES AS P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |
| EP-1879889-A1 | PROCESS FOR MAKING FLUORINATED 4-AZASTEROID DERIVATIVES AND INTERMEDIATE THEREOF | Merck & Co., Inc. (US) | 2008-01-23 | — | — | EP | disclosed |
| US-7301026-B2 | Process for making fluorinated 4-azasteroid derivatives | MERCK & CO., INC (US) | 2007-11-27 | — | — | US | disclosed |
| WO-2006121655-A1 | PROCESS FOR MAKING FLUORINATED 4-AZASTEROID DERIVATIVES AND INTERMEDIATE THEREOF | MERCK & CO., INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| US-20060252937-A1 | Process for making fluorinated 4-azasteroid derivatives | MERCK SHARP & DOHME CORP. | 2006-11-09 | — | — | US | disclosed |
| EP-1176959-B1 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | MERCK & CO INC (US) | 2006-03-08 | — | — | EP | disclosed |
| US-6579894-B2 | Bactericides, fungicides | MERCK & CO., INC. | 2003-06-17 | — | — | US | disclosed |
| US-20030013724-A1 | Novel prolines as antimicrobial agents | HAMMOND MILTON L (US) | 2003-01-16 | — | — | US | disclosed |
| US-6417217-B1 | TREATING INFECTIONS WITH HETEROCYCLIC MICROBIOCIDES THIS INVENTION RELATES TO THE FIELD OF TRANSFER RIBONUCLEIC ACID (TRNA) SYNTHETASE INHIBITORS, THEIR PREPARATION AND THEIR USE AS ANTIMICROBIAL ADMINISTERING TO THE SUBJECT A | MERCK & CO., INC. | 2002-07-09 | — | — | US | disclosed |
| US-6333344-B1 | ENZYME INHIBITORS AND BACTERICIDES | MERCK & CO. | 2001-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013724-A1 | Novel prolines as antimicrobial agents | AARS1, EPRS1, TRMT1 | NUDT1 266/4885CYP2C9 1873/4885NOS1 2168/4885 |
| US-20220106327-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, PNLIP, APOB | NUDT1 1139/4885CYP2C9 4414/4885NOS1 3294/4885 |
| US-20090325953-A1 | P38 KINASE INHIBITING AGENTS | MAPK1, MAPK8, MAPKAPK2 | NUDT1 1078/4885CYP2C9 1305/4885NOS1 95/4885 |
| US-20060252937-A1 | Process for making fluorinated 4-azasteroid derivatives | FSHR, CYP17A1, CYP19A1 | NUDT1 1804/4885CYP2C9 742/4885NOS1 904/4885 |
| US-20110105430-A1 | PYRROLO [2,3-C] PYRIDINE DERIVATIVES AS P38 KINEASE INHIBITING AGENTS | MAPK1, MAP3K8, MAPK8 | NUDT1 638/4885CYP2C9 1142/4885NOS1 592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.