Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332381 | 0.78 | RAB9A (0.50) | MEN1KMT2A | |
| SCHEMBL916682 | 0.74 | SIGMAR1 (0.65) | SIGMAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL355488 | 0.72 | SIGMAR1 (0.47) | SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL353209 | 0.72 | SIGMAR1 (0.47) | SIGMAR1SLC6A4 | |
| SCHEMBL5332672 | 0.70 | CA2 (0.40) | CYP2D6CA2 | |
| SCHEMBL356421 | 0.70 | SIGMAR1 (0.60) | SIGMAR1MEN1KMT2A | |
| SCHEMBL352861 | 0.69 | SIGMAR1 (0.46) | SIGMAR1CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL354689 | 0.69 | SLC2A1 (0.54) | SIGMAR1CYP3A4CYP2D6TP53 | |
| SCHEMBL918737 | 0.69 | APP (0.37) | EPHX2KMT2A | |
| SCHEMBL916714 | 0.69 | APP (0.37) | EPHX2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836161-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006085149-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-08-17 | — | — | WO | disclosed |