Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.73 |
| ▸ | HMGCR | P04035 | 4/20 | 0.73 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.73 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | PGR | P06401 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | RXRA | P19793 | 1/20 | 0.73 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.73 |
| ▸ | CCKAR | P32238 | 1/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.73 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332659 | 1.00 | CYP2C9 (0.73) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL5688703 | 0.93 | CYP2C9 (0.69) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL5688708 | 0.93 | CYP2C9 (0.69) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL5685977 | 0.93 | CYP2C9 (0.83) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL557533 | 0.93 | CYP2C9 (0.83) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL5685975 | 0.93 | CYP2C9 (0.83) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL4914699 | 0.90 | HMGCR (0.70) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL4914692 | 0.90 | HMGCR (0.70) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL4914702 | 0.90 | HMGCR (0.70) | CYP2C9HMGCRSIRT6ABCC3ABCB11 | |
| SCHEMBL6028729 | 0.90 | HMGCR (0.70) | CYP2C9HMGCRSIRT6ABCC3ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023503-A1 | A PROCESS FOR THE PREPARATION OF FLUVASTATIN SODIUM | USV LIMITED (IN) | 2007-03-01 | — | — | WO | disclosed |
| US-20040176614-A1 | Process for the preparation of indole derivatives and intermediates of the process | WOLLEB ANNEMARIE (CH) | 2004-09-09 | — | — | US | disclosed |
| US-6743926-B2 | FORMING SUCH AS 5-(3-(4-FLUOROPHENYL)-1-ISOPROPYL-1H-INDOL-2-YL)-3,5-DIHYDROXYPENT-2-ENOIC ACID METHYL ESTER | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-06-01 | — | — | US | disclosed |
| US-20030166946-A1 | Process for the preparation of indole derivatives and intermediates of the process | CIBA SPECIALTY CHEMICALS CORP. | 2003-09-04 | — | — | US | disclosed |
| EP-1284964-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES AND INTERMEDIATES OF THE PROCESS | Ciba SC Holding AG (CH) | 2003-02-26 | — | — | EP | disclosed |
| WO-2001092223-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES AND INTERMEDIATES OF THE PROCESS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166946-A1 | Process for the preparation of indole derivatives and intermediates of the process | TPH1, IDO1, TDO2 | CYP2C9 116/4885HMGCR 606/4885SIRT6 1105/4885 |
| US-20040176614-A1 | Process for the preparation of indole derivatives and intermediates of the process | TPH1, HTR4, TPH2 | CYP2C9 115/4885HMGCR 612/4885SIRT6 1064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.