Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314456 | 0.79 | EPHX2 (0.52) | CD274EPHX2CHRM4 | |
| SCHEMBL5333030 | 0.78 | DRD2 (0.49) | CD274DRD3DRD2DRD4POLB | |
| SCHEMBL5316471 | 0.78 | CD274 (0.56) | CD274NAMPTKCNH2EPHX2ALDH1A1 | |
| SCHEMBL5316201 | 0.77 | CD274 (0.51) | CD274NAMPTKCNH2EPHX2DRD3 | |
| SCHEMBL5314554 | 0.76 | KCNH2 (0.53) | CD274NAMPTKCNH2EPHX2DRD2 | |
| SCHEMBL5315537 | 0.76 | CD274 (0.48) | CD274NAMPTDRD3DRD2DRD1 | |
| SCHEMBL5320698 | 0.76 | CD274 (0.46) | CD274NAMPTKCNH2EPHX2KDM4E | |
| SCHEMBL5318392 | 0.76 | CD274 (0.58) | CD274NAMPTKCNH2EPHX2DRD3 | |
| SCHEMBL5336551 | 0.75 | EPHX2 (0.52) | CD274NAMPTKCNH2EPHX2CCR3 | |
| SCHEMBL5343476 | 0.75 | MCHR1 (0.49) | CD274KCNH2NPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |