Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599555 | 0.78 | CNR1 (0.42) | MAPK1LMNANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8601051 | 0.77 | ALDH1A1 (0.49) | CYP3A4TSHRTP53MAPK1LMNA | |
| SCHEMBL11308967 | 0.75 | MAOA (0.48) | TSHRTP53SMN1; SMN2CNR1MAOA | |
| SCHEMBL16563790 | 0.74 | ATR (0.49) | MAPK1LMNAALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL9965037 | 0.73 | MAPT (0.42) | CYP3A4MAPK1LMNANPC1CYP2D6 | |
| SCHEMBL28029191 | 0.73 | ALDH1A1 (0.49) | MAPK1LMNAALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL16389308 | 0.72 | L3MBTL1 (0.39) | TSHRMAPK1LMNACYP1A2CYP2C19 | |
| SCHEMBL8421994 | 0.71 | ALDH1A1 (0.55) | TSHRMAPK1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5333051 | 0.71 | ESR1 (0.50) | MAPK1LMNASMN1; SMN2L3MBTL1MAOA | |
| SCHEMBL7970564 | 0.71 | CYP19A1 (0.54) | CYP3A4LMNANPC1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | DEWDNEY NOLAN J | 2007-06-14 | — | — | US | disclosed |
| US-7189731-B2 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1620105-B1 | (6-(PHENOXY)-PYRIDO¬3,4-D|PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS SUCH AS RHEUMATOID ARTHRITIS | HOFFMANN LA ROCHE (CH) | 2007-01-10 | — | — | EP | disclosed |
| EP-1620105-A1 | (6-(PHENOXY)-PYRIDO[3,4-D]PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS SUCH AS RHEUMATOID ARTHRITIS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004091625-A1 | (6-(PHENOXY)-PYRIDO`3,4-D! PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORYY CONDITIONS SUCH AS RHEUMATOIS ARTRITIS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-28 | — | — | WO | disclosed |
| US-20040209903-A1 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | MAPK7, MAPK1, MAPK8 | CYP3A4 2203/4885TSHR 1743/4885TP53 1263/4885 |
| US-20040209903-A1 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | MAPK1, MAPK7, MAPK6 | CYP3A4 2933/4885TSHR 2700/4885TP53 1330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.