Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5292909 | 0.88 | HCAR2 (0.69) | HCAR2MEN1KMT2ACYP2C8CYP2C9 | |
| SCHEMBL5296880 | 0.87 | HCAR2 (0.57) | HCAR2MAPK8MAPK10PTPN2PTPN1 | |
| SCHEMBL14609517 | 0.80 | HCAR2 (0.52) | HCAR2MAPK8MAPK10NPC1RAB9A | |
| SCHEMBL5300950 | 0.79 | HCAR2 (0.50) | HCAR2MEN1KMT2AMAPK8MAPK10 | |
| SCHEMBL14609706 | 0.79 | HCAR2 (0.53) | HCAR2MAPK8MAPK10PTPN1LTB4R | |
| SCHEMBL5306921 | 0.78 | LTB4R (0.53) | HCAR2MEN1KMT2AMAPK8MAPK10 | |
| SCHEMBL5302041 | 0.78 | DHODH (0.52) | HCAR2KMT2AMAPK8MAPK10LTB4R | |
| SCHEMBL5303240 | 0.77 | RAB9A (0.56) | HCAR2MEN1KMT2AMAPK8MAPK10 | |
| SCHEMBL5309078 | 0.77 | LTB4R (0.54) | HCAR2MEN1KMT2AMAPK8MAPK10 | |
| SCHEMBL5309261 | 0.76 | HCAR2 (0.60) | HCAR2MEN1KMT2AMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |