Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 4/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309711 | 0.79 | GRM2 (0.41) | GRM2CDK9BRAFMAP4K4MEN1 | |
| SCHEMBL5311867 | 0.79 | MERTK (0.45) | MERTKMETFGFR3BTKAXL | |
| SCHEMBL5315261 | 0.77 | BDKRB1 (0.37) | MERTKMETCCNT1CDK9BTK | |
| SCHEMBL5313507 | 0.77 | DYRK2 (0.45) | MERTKMETFGFR3SRC | |
| SCHEMBL14531011 | 0.76 | BRAF (0.36) | MERTKMETF10GRM2BRAF | |
| SCHEMBL5314922 | 0.76 | PDE1B (0.35) | MERTKMETGRM2CCNT1CDK9 | |
| SCHEMBL5334782 | 0.69 | MERTK (0.43) | MERTKMETAXL | |
| SCHEMBL5311883 | 0.69 | TNIK (0.45) | MERTKGRM2KCNH2BTK | |
| SCHEMBL5335191 | 0.68 | MAPK8 (0.39) | MERTKMETCCNT1SRC | |
| SCHEMBL5314023 | 0.67 | KDR (0.47) | MERTKMETCDK9AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | disclosed |