Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HK1 | P19367 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330384 | 0.85 | ALDH1A1 (0.61) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL5332751 | 0.82 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL5124064 | 0.81 | ALDH1A1 (0.63) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL31329665 | 0.81 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL5529472 | 0.81 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL5531254 | 0.80 | KDM4E (0.57) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL5335435 | 0.80 | ALDH1A1 (0.57) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL5330885 | 0.79 | ALDH1A1 (0.56) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL5329339 | 0.78 | KDM4E (0.61) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL4303534 | 0.77 | LMNA (0.72) | ALDH1A1KDM4ESMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |