Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330885 | 0.99 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL5332751 | 0.97 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL5330384 | 0.84 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL31329665 | 0.80 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL5529472 | 0.80 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL5334103 | 0.80 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL8247183 | 0.80 | HIF1A (0.62) | CYP2C9NR1I2HIF1A | |
| SCHEMBL7078510 | 0.79 | CYP2C9 (0.52) | ALDH1A1SMN1; SMN2CYP2C9NR1I2HIF1A | |
| SCHEMBL8245604 | 0.79 | HIF1A (0.61) | CYP2C9NR1I2HIF1A | |
| SCHEMBL5329339 | 0.78 | KDM4E (0.61) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |