Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184219 | 0.84 | HRH3 (0.46) | HRH3PDE4BMAPK1MAPTTDP2 | |
| SCHEMBL14600407 | 0.83 | AXL (0.47) | HRH3PDE4BGPR119LMNASMN1; SMN2 | |
| SCHEMBL6401437 | 0.80 | PDE3B (0.42) | HRH3PDE4BSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9571268 | 0.78 | HRH3 (0.45) | HRH3PDE4BGAAKMT2AMAPK1 | |
| SCHEMBL7272141 | 0.77 | HRH3 (0.44) | HRH3PDE4BLMNAPOLBPTGS2 | |
| SCHEMBL11367905 | 0.76 | MAPT (0.44) | HRH3GAAKMT2AMAPK1MEN1 | |
| SCHEMBL16150009 | 0.75 | PDE3A (0.55) | RECQLALPLPDE4BKMT2AMAPK1 | |
| SCHEMBL11366945 | 0.74 | HRH3 (0.42) | HRH3RECQLPDE4BGPR119GAA | |
| SCHEMBL5183009 | 0.73 | TDP2 (0.41) | HRH3PDE4BMEN1TDP2PDE3B | |
| SCHEMBL6400233 | 0.72 | PDE4B (0.52) | HRH3PDE4BMAPK1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060605-A1 | Compositions and methods for inhibiting platelet activation and thrombosis | FLAUMENHAFT ROBERT C | 2007-03-15 | — | — | US | disclosed |
| US-7166612-B2 | Methods for reducing platelet activation platelet aggregaton or thrombosis | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2007-01-23 | — | — | US | disclosed |
| US-20040147540-A1 | Compositions and methods for inhibiting platelet activation and thrombosis | BETH ISRAEL DEACONESS MEDICAL CENTER | 2004-07-29 | — | — | US | disclosed |
| EP-1406621-A2 | COMPOSITIONS AND METHODS FOR INHIBITING PLATELET ACTIVATION AND THROMBOSIS | Beth Israel Deaconess Medical Center (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003001968-A2 | COMPOSITIONS AND METHODS FOR INHIBITING PLATELET ACTIVATION AND THROMBOSIS | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060605-A1 | Compositions and methods for inhibiting platelet activation and thrombosis | PLA2G7, PLTP, PLAAT2 | HRH3 3183/4885RECQL 4373/4885MAOB 2204/4885 |
| US-20040147540-A1 | Compositions and methods for inhibiting platelet activation and thrombosis | PLA2G7, PLTP, PLAAT2 | HRH3 3183/4885RECQL 4373/4885MAOB 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.