Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571268 | 0.89 | HRH3 (0.45) | PDE3BPDE3AHRH3PDE4BGALR3 | |
| SCHEMBL11366945 | 0.84 | HRH3 (0.42) | PDE3BPDE3AHRH3PDE4BGALR3 | |
| SCHEMBL6400233 | 0.82 | PDE4B (0.52) | PDE3BPDE3AHRH3PDE4BPDE4A | |
| SCHEMBL14491901 | 0.81 | HRH3 (0.42) | PDE3BPDE3AHRH3PDE4BGALR3 | |
| SCHEMBL5335003 | 0.80 | HRH3 (0.46) | PDE3BPDE3AHRH3PDE4BMAPT | |
| SCHEMBL5184219 | 0.80 | HRH3 (0.46) | PDE3BPDE3AHRH3BACE1PDE4B | |
| SCHEMBL11367905 | 0.80 | MAPT (0.44) | PDE3BPDE3AHRH3GALR3MAPT | |
| SCHEMBL5337178 | 0.78 | MAPT (0.59) | PDE3BPDE3AHRH3PDE4BGALR3 | |
| SCHEMBL5183009 | 0.78 | TDP2 (0.41) | PDE3BPDE3AHRH3PDE4B | |
| SCHEMBL8720091 | 0.74 | HRH3 (0.41) | PDE3BPDE3AHRH3PDE4BGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059658-A1 | Pyridazinone | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059658-A1 | Pyridazinone | TYMP, TPMT, PDXK | PDE3B 1587/4885PDE3A 1579/4885HRH3 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.