Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 9/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533538 | 0.90 | MCL1 (0.39) | ACLYPOLBMEN1KMT2AHSD17B2 | |
| SCHEMBL533016 | 0.85 | ALPL (0.49) | ACLYWDR5MAPT | |
| SCHEMBL534077 | 0.84 | TSHR (0.47) | POLBMEN1KMT2AMAPTCYTH2 | |
| SCHEMBL533083 | 0.82 | EDNRA (0.46) | POLBJAK2MAPT | |
| SCHEMBL10092353 | 0.81 | POLB (0.33) | POLBMEN1KMT2AJAK2MAPT | |
| SCHEMBL532980 | 0.81 | JAK2 (0.48) | POLBMEN1KMT2AJAK2MAPT | |
| SCHEMBL8314837 | 0.80 | MAPT (0.39) | POLBMEN1KMT2AJAK2MAPT | |
| SCHEMBL532776 | 0.79 | FFAR4 (0.54) | POLBMEN1KMT2AMAPTCYTH2 | |
| SCHEMBL533957 | 0.79 | TP53 (0.39) | POLBMEN1KMT2AMAPTCYTH2 | |
| SCHEMBL532939 | 0.78 | EDNRA (0.43) | POLBMEN1KMT2AJAK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |