Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533538 | 0.91 | MCL1 (0.39) | MAPTPOLBJAK2MEN1KMT2A | |
| SCHEMBL533112 | 0.89 | ALPL (0.46) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL532980 | 0.86 | JAK2 (0.48) | MAPTPOLBJAK2MEN1KMT2A | |
| SCHEMBL533083 | 0.83 | EDNRA (0.46) | MAPTPOLBJAK2SMN1; SMN2ALDH1A1 | |
| SCHEMBL533578 | 0.80 | ACLY (0.43) | MAPTPOLBJAK2MEN1KMT2A | |
| SCHEMBL532038 | 0.78 | ALDH1A1 (0.54) | MAPTPOLBJAK2KMT2AALDH1A1 | |
| SCHEMBL534077 | 0.78 | TSHR (0.47) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL532939 | 0.78 | EDNRA (0.43) | MAPTPOLBJAK2MEN1KMT2A | |
| SCHEMBL534052 | 0.78 | MEN1 (0.47) | MAPTPOLBJAK2MEN1KMT2A | |
| SCHEMBL533016 | 0.78 | ALPL (0.49) | MAPTALDH1A1CYP3A4CYP2C9BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004073634-A2 | PHENYLENEDIAMINE UROTENSIN-II RECEPTOR ANTAGONISTS AND CCR-9 ANTAGONISTS | ENCYSIVE PHARMACEUTICALS INC. (US) | 2004-09-02 | — | — | WO | disclosed |