Sugi Predict

Sugi Predict / Compounds / SCHEMBL5336434

SCHEMBL5336434

SCHEMBL5336434

CNC(=O)Cc1ccc(C2=C(C(=O)O)N3C(=O)[C@H]([C@@H](C)O)[C@H]3C2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.42
▸ LMNA P02545 1/20 0.42
▸ ESR1 P03372 1/20 0.39
▸ CHRM1 P11229 1/20 0.39
▸ SLC6A4 P31645 1/20 0.39
▸ KCNH2 Q12809 1/20 0.39
▸ SLC29A1 Q99808 1/20 0.39
▸ MAPK1 P28482 1/20 0.37
▸ TDP1 Q9NUW8 2/20 0.36
▸ MAPT P10636 2/20 0.36
▸ POLB P06746 1/20 0.36
▸ PKM P14618 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ DUSP3 P51452 1/20 0.36
▸ PTPN5 P54829 1/20 0.36
▸ PTPN11 Q06124 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.33
▸ HPGD P15428 1/20 0.33
▸ ELANE P08246 2/20 0.32
▸ HDAC4 P56524 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5337160 0.88 KDM4E (0.39) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL5343892 0.87 LMNA (0.45) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL14517639 0.87 KDM4E (0.39) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL5352932 0.86 MAPK1 (0.34) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL5345227 0.86 KDM4E (0.45) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL6541980 0.86 LMNA (0.41) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL6541975 0.86 LMNA (0.41) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL5338330 0.86 LMNA (0.41) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL14517596 0.86 KDM4E (0.41) KDM4ELMNAESR1CHRM1SLC6A4
SCHEMBL5341317 0.86 RAB9A (0.44) KDM4ELMNAESR1CHRM1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7205291-B2 High mouth absorption; antibiotics against gramnegative, grampositive bacteria espscially Staphlococcus pneumonia, Hemophilus influenza DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-04-17 — — US disclosed
US-7205291-B2 High mouth absorption; antibiotics against gramnegative, grampositive bacteria espscially Staphlococcus pneumonia, Hemophilus influenza DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-04-17 — — US disclosed
US-7205291-B2 High mouth absorption; antibiotics against gramnegative, grampositive bacteria espscially Staphlococcus pneumonia, Hemophilus influenza DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-04-17 — — US disclosed
US-20050020566-A1 Novel carbapenem compounds DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2005-01-27 — — US disclosed
EP-1443047-A1 NOVEL CARBAPENEM COMPOUNDS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2004-08-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050020566-A1 Novel carbapenem compounds HPN, PRSS1, BPGM KDM4E 3734/4885LMNA 366/4885ESR1 4684/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.