Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974262 | 0.75 | PRMT5 (0.52) | SMOMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2485236 | 0.74 | CCR5 (0.48) | SMOMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4753305 | 0.74 | NPC1 (0.53) | SMONPC1RAB9ATSHRTDP1 | |
| SCHEMBL3322956 | 0.73 | SMO (0.59) | SMOMEN1KMT2ANPC1RAB9A | |
| SCHEMBL12770960 | 0.73 | MEN1 (0.68) | SMOMEN1KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2486769 | 0.72 | CCR5 (0.69) | SMOCYP3A4OPRM1CCR5 | |
| SCHEMBL18894670 | 0.72 | COMT (0.64) | SMO | |
| SCHEMBL9961742 | 0.72 | SMO (0.57) | SMOMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11250227 | 0.71 | MEN1 (0.66) | MEN1KMT2ANPC1RAB9ATSHR | |
| Hydrochloric Acid SCHEMBL3320989 | 0.71 | SMO (0.56) | SMOMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285552-B2 | Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient | ONO PHARMACEUTICALS CO., LTD. (JP) | 2007-10-23 | — | — | US | disclosed |
| US-7262193-B2 | Triazaspiro[5.5]undecane derivative and pharmaceutical composition comprising the same as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| CN-1291988-C | Triazaspiro [5,5] undecane derivatrives and drugs containing the same as active ingredient | ONO PHARMACEUTICAL CO (JP) | 2006-12-27 | — | — | CN | disclosed |
| US-7053090-B2 | Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-05-30 | — | — | US | disclosed |
| EP-1619194-A2 | Triazaspiro[5.5]undecane derivatives and pharmaceutical composition comprising the same as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-01-25 | — | — | EP | disclosed |
| US-20050215557-A1 | Triazaspiro[5.5]undecane derivative and pharmaceutical composition comprising the same as active ingredient | ONO PHARMACEUTICAL CO., LTD. | 2005-09-29 | — | — | US | disclosed |
| CN-1533390-A | Pharmaceutical composition comprising triazaspiro [5.5] undecane derivative as active ingredient | СҰҩƷ��ҵ��ʽ���� | 2004-09-29 | — | — | CN | disclosed |
| CN-1518551-A | Triazaspiro [5,5] undecane derivatrives and drugs containing the same as active ingredient | СҰҩƷ��ҵ��ʽ���� | 2004-08-04 | — | — | CN | disclosed |
| US-20040106619-A1 | Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient | ONO PHARMACEUTICALS CO., LTD. (JP) | 2004-06-03 | — | — | US | disclosed |
| US-20040082584-A1 | Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-04-29 | — | — | US | disclosed |
| EP-1378509-A1 | DRUGS CONTAINING TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-01-07 | — | — | EP | disclosed |
| EP-1378510-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106619-A1 | Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient | NONO, NAA15, USO1 | SMO 4255/4885MEN1 4685/4885KMT2A 2233/4885 |
| US-20040082584-A1 | Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient | ACKR3, CXCR5, CCL11 | SMO 4702/4885MEN1 4856/4885KMT2A 4257/4885 |
| US-20050215557-A1 | Triazaspiro[5.5]undecane derivative and pharmaceutical composition comprising the same as active ingredient | ACKR3, CCL11, CCR7 | SMO 4725/4885MEN1 4836/4885KMT2A 4058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.