Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557210 | 0.90 | REN (0.50) | RENKCNH2CYP3A4NR1H4KMT2A | |
| SCHEMBL533824 | 0.84 | REN (0.67) | RENKCNH2CYP3A4NR1H4 | |
| SCHEMBL3719090 | 0.83 | REN (0.68) | RENKCNH2CYP3A4 | |
| SCHEMBL557211 | 0.82 | REN (0.46) | RENKCNH2CYP3A4NR1H4 | |
| SCHEMBL556389 | 0.82 | REN (0.80) | RENKCNH2CYP3A4 | |
| SCHEMBL557036 | 0.80 | REN (0.60) | RENKCNH2CYP3A4NR1H4 | |
| SCHEMBL555815 | 0.75 | REN (0.61) | RENKCNH2CYP3A4 | |
| SCHEMBL555742 | 0.74 | REN (0.62) | RENKCNH2CYP3A4 | |
| SCHEMBL555594 | 0.73 | REN (0.63) | RENKCNH2CYP3A4KMT2A | |
| SCHEMBL533844 | 0.73 | REN (0.63) | RENKCNH2CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |