Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30059668 | 0.81 | G6PD (0.43) | ALDH1A1TDP1TSHRCYP2A6CYP3A4 | |
| SCHEMBL6789873 | 0.81 | G6PD (0.43) | ALDH1A1TDP1TSHRCYP2A6CYP3A4 | |
| SCHEMBL5256400 | 0.79 | TDP1 (0.50) | ALDH1A1TDP1TSHRCYP3A4MAPT | |
| SCHEMBL10375442 | 0.77 | CYP2A6 (0.57) | ALDH1A1TDP1TSHRCYP2A6CYP3A4 | |
| SCHEMBL2844302 | 0.76 | ALDH1A1 (0.51) | ALDH1A1TDP1CYP3A4MAPTMEN1 | |
| SCHEMBL4263947 | 0.76 | TSHR (0.42) | ALDH1A1TSHRCYP2A6MAPTMEN1 | |
| SCHEMBL6790964 | 0.74 | KMT2A (0.53) | ALDH1A1TDP1TSHRCYP3A4MAPT | |
| SCHEMBL9049774 | 0.74 | MAPT (0.57) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL2845980 | 0.74 | NPC1 (0.46) | ALDH1A1TDP1MAPTMEN1POLB | |
| SCHEMBL11177470 | 0.74 | MTNR1A (0.44) | ALDH1A1TDP1MAPTPOLBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
| EP-0292885-B1 | CATALYTIC TRANSFER-HYDROGENATION WITH AROMATIC NITRO COMPOUNDS AS HYDROGEN ACCEPTOR | BASF Aktiengesellschaft (DE) | 1993-09-08 | — | — | EP | disclosed |
| US-4816461-A | 7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b] indole, a process for their preparation and medicaments containing them | TROPONWERKE GMBH & CO. KG (DE) | 1989-03-28 | — | — | US | disclosed |
| EP-0292885-A2 | Catalytic transfer-hydrogenation with aromatic nitro compounds as hydrogen acceptor | BASF Aktiengesellschaft (DE) | 1988-11-30 | — | — | EP | disclosed |
| EP-0120439-B1 | 7,8,9,10-TETRAHYDROTHIENO-(3,2-E)-PYRIDO-(4,3-B)-INDOLES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1987-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | ALDH1A1 378/4885TDP1 3589/4885TSHR 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.