Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 12/20 | 0.59 |
| ▸ | PTGES | O14684 | 9/20 | 0.59 |
| ▸ | PPARA | Q07869 | 13/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL555956 | 0.80 | PPARG (0.37) | PPARGALOX5PTGESPPARAPPARD | |
| SCHEMBL533934 | 0.75 | ALDH1A1 (0.42) | PPARG | |
| SCHEMBL533935 | 0.75 | PPARG (0.41) | PPARGALOX5PTGESPPARA | |
| SCHEMBL31046596 | 0.73 | PPARG (0.53) | PPARGALOX5PTGESPPARA | |
| SCHEMBL8904270 | 0.73 | PPARG (0.53) | PPARGALOX5PTGESPPARA | |
| SCHEMBL17400006 | 0.73 | ADRB2 (0.40) | PPARGALOX5PTGES | |
| SCHEMBL13652565 | 0.72 | CA12 (0.47) | — | |
| Hydrochloric Acid SCHEMBL8719650 | 0.72 | PPARG (0.52) | PPARGALOX5PTGESPPARA | |
| SCHEMBL8257155 | 0.72 | SLC6A4 (0.40) | — | |
| SCHEMBL533960 | 0.70 | CYP2D6 (0.42) | PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |