Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.37 |
| ▸ | PPARD | Q03181 | 5/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533933 | 0.80 | PPARG (0.59) | PPARGPPARDPPARAPTGESALOX5 | |
| SCHEMBL8257155 | 0.74 | SLC6A4 (0.40) | KDM4EHTR1ACYP2D6SLC6A4SMN1; SMN2 | |
| SCHEMBL555958 | 0.74 | KDM4E (0.36) | PPARGPPARDPPARAKDM4EACACB | |
| SCHEMBL555957 | 0.73 | MTNR1A (0.38) | PPARGHTR1ACYP2D6SLC6A4SMN1; SMN2 | |
| SCHEMBL8259521 | 0.72 | SLC6A4 (0.41) | KDM4EHTR1ACYP2D6SLC6A4TDP1 | |
| SCHEMBL533873 | 0.72 | SLC6A4 (0.41) | KDM4EHTR1ACYP2D6SLC6A4TDP1 | |
| SCHEMBL533960 | 0.70 | CYP2D6 (0.42) | PPARGKDM4EHTR1ACYP2D6SLC6A4 | |
| SCHEMBL534207 | 0.70 | SLC6A4 (0.40) | KDM4EHTR1ACYP2D6SLC6A4SMN1; SMN2 | |
| SCHEMBL2134422 | 0.69 | PPARG (0.40) | PPARGPPARAPTGESALOX5KDM4E | |
| SCHEMBL15957231 | 0.68 | ITGB3 (0.47) | PPARGKDM4ECYP2D6TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | PPARG 1244/4885PPARD 420/4885PPARA 1101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.