Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.41 |
| ▸ | PPARA | Q07869 | 7/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8136073 | 0.82 | PPARG (0.43) | PPARGPPARAALOX5MMP9MMP8 | |
| SCHEMBL4666766 | 0.79 | TAS1R3 (0.41) | MMP9MMP8MMP13 | |
| SCHEMBL555958 | 0.79 | KDM4E (0.36) | PPARGPPARA | |
| SCHEMBL8130408 | 0.79 | THRA (0.43) | PPARGPPARAALOX5MMP9MMP8 | |
| SCHEMBL533933 | 0.75 | PPARG (0.59) | PPARGPPARAALOX5PTGES | |
| SCHEMBL8132546 | 0.73 | HDAC3 (0.44) | PPARGPPARAALOX5 | |
| SCHEMBL8129412 | 0.73 | FFAR1 (0.40) | PPARGPPARAALOX5MMP9MMP8 | |
| SCHEMBL8120029 | 0.73 | FFAR1 (0.47) | MMP9MMP8MMP13THRATHRB | |
| SCHEMBL8129258 | 0.73 | FFAR1 (0.43) | PPARGPPARAALOX5MMP9MMP8 | |
| SCHEMBL8129124 | 0.71 | FFAR1 (0.51) | PPARGALOX5PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |