⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359756 | 0.75 | ADH1B (0.34) | — | |
| SCHEMBL10896628 | 0.75 | MMP8 (0.32) | — | |
| SCHEMBL11381438 | 0.75 | ATM (0.35) | — | |
| SCHEMBL8580441 | 0.74 | — | — | |
| SCHEMBL11296279 | 0.72 | — | — | |
| SCHEMBL6716656 | 0.71 | ALDH1A1 (0.32) | — | |
| SCHEMBL29242155 | 0.70 | — | — | |
| SCHEMBL10859017 | 0.69 | ALDH1A1 (0.30) | — | |
| SCHEMBL1536734 | 0.69 | — | — | |
| SCHEMBL2275108 | 0.69 | TDP1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170240539-A1 | Preparation and Use of Cyclic Sulfonamide Derivatives as PAR-1 Receptor Antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-08-24 | — | — | US | disclosed |
| US-20170240539-A1 | Preparation and Use of Cyclic Sulfonamide Derivatives as PAR-1 Receptor Antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-08-24 | — | — | US | disclosed |
| US-20170240539-A1 | Preparation and Use of Cyclic Sulfonamide Derivatives as PAR-1 Receptor Antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-08-24 | — | — | US | disclosed |
| EP-3206687-A1 | PREPARATION AND USE OF CYCLIC SULFONAMIDE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2017-08-23 | — | — | EP | disclosed |
| WO-2016060940-A1 | PREPARATION AND USE OF CYCLIC SULFONAMIDE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-04-21 | — | — | WO | disclosed |
| WO-2016058144-A1 | PREPARATION AND USE OF CYCLIC SULFONAMIDE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-04-21 | — | — | WO | disclosed |
| WO-2016060940-A1 | PREPARATION AND USE OF CYCLIC SULFONAMIDE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-04-21 | — | — | WO | disclosed |
| US-7288650-B2 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2007-10-30 | — | — | US | disclosed |
| US-7074793-B2 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-20060128780-A1 | Cyclic substituted fused pyrrolocarbazoles and isoindolones | CEPHALON, INC. (US) | 2006-06-15 | — | — | US | disclosed |
| WO-2002014536-A2 | ODULATING MULTIPLE LINEAGE KINASE PROTEINS | CEPHALON, INC. (US) | 2002-02-21 | — | — | WO | disclosed |
| EP-1165562-A1 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | Cephalon, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1083903-A4 | BRIDGED INDENOPYRROLOCARBAZOLES | CEPHALON INC (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000047583-A9 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | CEPHALON INC (US) | 2001-09-20 | — | — | WO | disclosed |
| EP-1105728-A1 | MODULATING MULTIPLE LINEAGE KINASE PROTEINS | CEPHALON, INC. (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1083903-A1 | BRIDGED INDENOPYRROLOCARBAZOLES | CEPHALON, INC. (US) | 2001-03-21 | — | — | EP | disclosed |
| US-6127401-A | TREATMENT OF PROSTATE DISORDERS, ANGIOGENIC DISORDERS, NEOPLASIA, RHEUMATOID ARTHRITIS, PULMONARY FIBROSIS, MYELOFIBROSIS, ABNORMAL WOUND HEALING, ATHEROSCLEROSIS, OR RESTENOSIS, ALZHEIMER'S DISEASE | CEPHALON, INC. (US) | 2000-10-03 | — | — | US | disclosed |
| WO-2000047583-A1 | CYCLIC SUBSTITUTED FUSED PYRROLOCARBAZOLES AND ISOINDOLONES | CEPHALON, INC. (US) | 2000-08-17 | — | — | WO | disclosed |
| WO-2000013015-A1 | MODULATING MULTIPLE LINEAGE KINASE PROTEINS | CEPHALON, INC. (US) | 2000-03-09 | — | — | WO | disclosed |
| WO-1999062523-A1 | BRIDGED INDENOPYRROLOCARBAZOLES | CEPHALON, INC. (US) | 1999-12-09 | — | — | WO | disclosed |