Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776003 | 0.85 | MGLL (0.48) | — | |
| SCHEMBL5172182 | 0.84 | MCL1 (0.46) | SMN1; SMN2 | |
| SCHEMBL3088285 | 0.84 | MCL1 (0.46) | SMN1; SMN2 | |
| SCHEMBL3515032 | 0.84 | MGLL (0.43) | SLC6A2SLC6A3 | |
| SCHEMBL3518717 | 0.84 | HPGD (0.51) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3515035 | 0.84 | MGLL (0.43) | SLC6A2SLC6A3 | |
| SCHEMBL3518713 | 0.84 | HPGD (0.51) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3515523 | 0.83 | LMNA (0.53) | SMN1; SMN2HSD11B1 | |
| SCHEMBL3515528 | 0.83 | LMNA (0.53) | SMN1; SMN2HSD11B1 | |
| SCHEMBL20482718 | 0.81 | THRB (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117557-A2 | DIAMINOPROPANOL RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |