Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | F9 | P00740 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.35 |
| ▸ | PRNP | P04156 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5343019 | 0.90 | PTPN1 (0.44) | HDAC6PTPN1RXFP1PRNPHDAC3 | |
| SCHEMBL5337091 | 0.83 | RXFP1 (0.46) | PTPN1F9RXFP1PRNPF10 | |
| SCHEMBL5808917 | 0.83 | HDAC6 (0.39) | HDAC6PTPN1HDAC3HDAC1HDAC2 | |
| SCHEMBL5809067 | 0.82 | HDAC6 (0.39) | HDAC6PTPN1HDAC3HDAC1HDAC2 | |
| SCHEMBL5340347 | 0.73 | F9 (0.41) | PTPN1F9RXFP1PRNPF10 | |
| SCHEMBL5338896 | 0.72 | F9 (0.45) | F9F10ESR1LMNAERN1 | |
| SCHEMBL5335756 | 0.71 | RXFP1 (0.56) | RXFP1PRNPLMNAALDH1A1KDM4E | |
| SCHEMBL5341879 | 0.70 | F9 (0.41) | PTPN1F9RXFP1PRNPF10 | |
| SCHEMBL6579998 | 0.69 | KDM4E (0.44) | PTPN1RXFP1PRNPLMNAALDH1A1 | |
| SCHEMBL5337137 | 0.68 | F9 (0.41) | PTPN1F9RXFP1PRNPF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163954-B2 | Substituted naphthyl benzothiophene acids | WYETH (US) | 2007-01-16 | — | — | US | disclosed |
| EP-1664015-A1 | SUBSTITUTED NAPHTHYL BENZOTHIOPHENE ACIDS | Wyeth (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005030750-A1 | SUBSTITUTED NAPHTHYL BENZOTHIOPHENE ACIDS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
| US-20050070587-A1 | Substituted naphthyl benzothiophene acids | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070587-A1 | Substituted naphthyl benzothiophene acids | TST, GNPAT, NUDT1 | HDAC6 963/4885PTPN1 1717/4885F9 4698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.