Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532776 | 0.88 | FFAR4 (0.54) | TP53KMT2AMEN1FFAR4ALDH1A1 | |
| SCHEMBL14288683 | 0.88 | RAD52 (0.53) | TP53RAD52KMT2AMEN1EDNRA | |
| SCHEMBL533534 | 0.88 | POLB (0.47) | TP53KMT2AMEN1FFAR4ALDH1A1 | |
| SCHEMBL534044 | 0.87 | MAPT (0.43) | TP53KMT2AMEN1FFAR4ALDH1A1 | |
| SCHEMBL533017 | 0.86 | FFAR4 (0.55) | TP53KMT2AMEN1FFAR4ALDH1A1 | |
| SCHEMBL533137 | 0.85 | RXFP1 (0.50) | SLC40A1MAPT | |
| SCHEMBL533006 | 0.85 | HTR6 (0.43) | TP53KMT2AMEN1FFAR4ALDH1A1 | |
| SCHEMBL5112344 | 0.82 | SLC40A1 (0.47) | TP53FFAR4SLC40A1ALDH1A1MAPT | |
| SCHEMBL3973255 | 0.82 | RAD52 (0.43) | TP53RAD52KMT2AMEN1EDNRA | |
| SCHEMBL534077 | 0.81 | TSHR (0.47) | TP53KMT2AMEN1EDNRAFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |