Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 10/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533017 | 0.88 | FFAR4 (0.55) | MAPTALDH1A1POLBSMN1; SMN2FFAR4 | |
| SCHEMBL534045 | 0.87 | TP53 (0.48) | MAPTALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL532991 | 0.86 | MAPT (0.47) | MAPTALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL533055 | 0.85 | ALDH1A1 (0.45) | MAPTALDH1A1POLBSMN1; SMN2FFAR4 | |
| SCHEMBL532776 | 0.85 | FFAR4 (0.54) | MAPTALDH1A1POLBFFAR4RECQL | |
| SCHEMBL532881 | 0.83 | GAA (0.39) | MAPTALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL532880 | 0.83 | FFAR4 (0.56) | MAPTALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL533437 | 0.83 | CYTH2 (0.49) | MAPTALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL533666 | 0.83 | FFAR4 (0.56) | MAPTALDH1A1POLBHTTFFAR4 | |
| SCHEMBL532953 | 0.81 | FFAR4 (0.59) | MAPTALDH1A1SMN1; SMN2FFAR4GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |