Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | GAA | P10253 | 4/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | CFTR | P13569 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12598054 | 0.87 | ALDH1A1 (0.69) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL17080825 | 0.84 | ALDH1A1 (0.66) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL25230816 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL940556 | 0.83 | ALDH1A1 (0.57) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL534527 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL26466965 | 0.81 | ALDH1A1 (0.76) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL30041521 | 0.81 | ALDH1A1 (1.00) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL1809277 | 0.81 | ALDH1A1 (1.00) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL221403 | 0.81 | ALDH1A1 (0.81) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL1071828 | 0.80 | HPGD (0.49) | ALDH1A1KDM4EGAAHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | ALDH1A1 900/4885KDM4E 2653/4885GAA 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.