Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.63 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5336638 | 0.99 | OPRL1 (0.62) | OPRL1OPRM1NPY5RBCHEACHE | |
| SCHEMBL6168849 | 0.88 | OPRL1 (0.59) | OPRL1OPRM1BCHEACHEHTT | |
| Hydrochloric Acid SCHEMBL5339275 | 0.88 | OPRL1 (0.60) | OPRL1OPRM1BCHEACHEKMT2A | |
| SCHEMBL6165082 | 0.87 | OPRL1 (0.58) | OPRL1OPRM1BCHEACHEHTT | |
| SCHEMBL5165880 | 0.87 | OPRL1 (0.73) | OPRL1OPRM1NPY5RBCHEACHE | |
| SCHEMBL5349434 | 0.86 | OPRL1 (0.72) | OPRL1OPRM1BCHEACHELMNA | |
| SCHEMBL2378435 | 0.86 | OPRL1 (0.66) | OPRL1OPRM1BCHEACHELMNA | |
| Hydrochloric Acid SCHEMBL5167184 | 0.86 | OPRL1 (0.72) | OPRL1OPRM1NPY5RBCHEACHE | |
| Hydrochloric Acid SCHEMBL5336014 | 0.85 | OPRL1 (0.71) | OPRL1OPRM1BCHEACHELMNA | |
| SCHEMBL4855428 | 0.85 | OPRL1 (0.66) | OPRL1OPRM1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173045-B2 | 4-aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2007-02-06 | — | — | US | disclosed |
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2005-11-03 | — | — | US | disclosed |
| EP-1562891-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043899-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | HNMT, PNMT, INMT | OPRL1 378/4885OPRM1 69/4885NPY5R 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.