Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 13/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11839484 | 0.83 | HRH3 (0.58) | HRH3SIGMAR1NPY5RHSD11B1CYP2D6 | |
| SCHEMBL2001104 | 0.80 | HRH3 (0.66) | HRH3SIGMAR1NPY5RHSD11B1CYP2D6 | |
| SCHEMBL3860397 | 0.80 | SIGMAR1 (0.60) | HRH3SIGMAR1NPY5RHSD11B1CYP2D6 | |
| SCHEMBL11842983 | 0.80 | NPY5R (0.56) | HRH3SIGMAR1NPY5RHSD11B1CYP2D6 | |
| SCHEMBL5786578 | 0.79 | NPY5R (0.55) | HRH3NPY5R | |
| SCHEMBL1995597 | 0.79 | HRH3 (0.65) | HRH3SIGMAR1NPY5RHSD11B1CYP2D6 | |
| SCHEMBL6427482 | 0.78 | SIGMAR1 (0.56) | HRH3SIGMAR1NPY5R | |
| Hydrochloric Acid SCHEMBL4045751 | 0.78 | SIGMAR1 (0.54) | HRH3SIGMAR1NPY5RHSD11B1CYP2D6 | |
| SCHEMBL11840173 | 0.77 | HRH3 (0.55) | HRH3SIGMAR1NPY5RHSD11B1CYP2D6 | |
| SCHEMBL3952096 | 0.77 | HRH3 (1.00) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-09-06 | — | — | US | claimed |
| WO-2007103719-A2 | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007103719-A2 | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-09-06 | — | — | US | disclosed |
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-09-06 | — | — | US | disclosed |
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | HSD11B1, HSD17B1, HSD3B1 | HRH3 2984/4885SIGMAR1 1983/4885NPY5R 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.