Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | TACR1 | P25103 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 2/20 | 0.31 |
| ▸ | LCT | P09848 | 2/20 | 0.31 |
| ▸ | UGCG | Q16739 | 2/20 | 0.31 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556773 | 0.79 | OPRK1 (0.38) | RENKCNH2TACR1GBA1LCT | |
| SCHEMBL557213 | 0.70 | OPRK1 (0.33) | RENKCNH2TACR1 | |
| SCHEMBL534235 | 0.70 | OPRK1 (0.35) | RENKCNH2TACR1 | |
| SCHEMBL534386 | 0.70 | OPRK1 (0.33) | RENKCNH2TACR1 | |
| SCHEMBL534387 | 0.70 | OPRK1 (0.33) | RENKCNH2TACR1 | |
| SCHEMBL6042929 | 0.68 | DRD2 (0.36) | RENKCNH2CYP3A4SLC6A4 | |
| SCHEMBL533936 | 0.68 | REN (0.35) | RENKCNH2CYP3A4SLC6A4 | |
| SCHEMBL10264145 | 0.68 | ALDH1A1 (0.37) | TACR1CYP3A4 | |
| SCHEMBL533965 | 0.67 | IDO1 (0.38) | CYP3A4 | |
| SCHEMBL10202421 | 0.66 | APP (0.39) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |