SCHEMBL5345508

SCHEMBL5345508

O=C(O)[C@@H](O)Cc1ccc(OCCN2c3ccccc3Oc3ccccc32)cc1

nearest known ligand 0.72

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PPARG P37231 9/20 0.72
PPARA Q07869 8/20 0.72
PPARD Q03181 4/20 0.48
CACNA1B Q00975 7/20 0.43
CACNA1H O95180 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6004633 1.00 PPARG (0.72) PPARGPPARAPPARDCACNA1BCACNA1H
SCHEMBL7514537 0.91 PPARG (0.74) PPARGPPARAPPARDCACNA1BCACNA1H
SCHEMBL5342143 0.87 PPARG (0.70) PPARGPPARAPPARDCACNA1BCACNA1H
SCHEMBL7928584 0.85 PPARG (0.81) PPARGPPARAPPARD
SCHEMBL6002510 0.85 PPARG (0.77) PPARGPPARA
Ragaglitazar SCHEMBL676872 0.84 PPARA (1.00) PPARGPPARAPPARD
Ragaglitazar SCHEMBL29369224 0.84 PPARA (1.00) PPARGPPARAPPARD
Ragaglitazar SCHEMBL682732 0.84 PPARA (1.00) PPARGPPARAPPARD
Ragaglitazar SCHEMBL4822459 0.84 PPARA (1.00) PPARGPPARAPPARD
Homatropine SCHEMBL5342141 0.82 LMNA (0.55) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7223881-B2 Process for the preparation of new antidiabetic agents DR. REDDY'S LABORATORIES LIMITED (IN) 2007-05-29 US disclosed
US-20030125553-A1 Process for the preparation of new antidiabetic agents DR. REDDY'S LABORATORIES LIMITED 2003-07-03 US disclosed
WO-2003027084-A1 IMPROVED PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE PHENOXAZINE DERIVATIVES AS ANTIDIABETIC AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2003-04-03 WO disclosed
US-6531596-B1 S(-)-2-methoxy-3-(4-(2-(phenoxazin-10-yl)methoxy) phenyl)propionic acid; benzylating p-hydroxybenzaldehyde or tyrosine; reaction with phenoxazinyl mesylate DR. REDDY'S LABORATORIES LTD. (IN) 2003-03-11 US disclosed
WO-2003008397-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF ANTIDIABETIC PHENOXAZINE COMPOUNDS DR. REDDY'S LABORATORIES LTD. (IN) 2003-01-30 WO disclosed
EP-1124808-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF NEW ANTIDIABETIC AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2001-08-22 EP disclosed
WO-2000026200-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF NEW ANTIDIABETIC AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-05-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030125553-A1 Process for the preparation of new antidiabetic agents GLP1R, GPR119, SLC5A1 PPARG 103/4885PPARA 108/4885PPARD 69/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.